Mechanisms of Lipotoxicity in the Cardiovascular System
Author:
Publisher
Springer Science and Business Media LLC
Subject
Internal Medicine
Link
http://link.springer.com/content/pdf/10.1007/s11906-012-0307-2.pdf
Reference120 articles.
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3. • Rask-Madsen C, Li Q, Freund B, et al. Loss of insulin signaling in vascular endothelial cells accelerates atherosclerosis in apolipoprotein E null mice. Cell Metab. 2010;11:379–89. Evidence is provided that loss of insulin signaling in endothelium increases atherosclerotic lesion formation in part via a mechanism mediated by impaired eNOS activation.
4. • Maeno Y, Li Q, Park K, et al. Inhibition of insulin signaling in endothelial cells by protein kinase C-induced phosphorylation of p85 subunit of phosphatidylinositol 3-kinase (PI3K). J Biol Chem. 2012;287:4518–30. This study identified a molecular mechanisms by which activation of PKC inhibits IRS1-mediated PI3K activation of eNOS via phosphorylation of the p85 subunit of PI3K.
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