Evolving strategies for the use of combination therapy in hypertension
Author:
Publisher
Springer Science and Business Media LLC
Subject
Internal Medicine
Link
http://link.springer.com/content/pdf/10.1007/s11906-002-0062-x.pdf
Reference19 articles.
1. Hyman DJ, Pavlik VN: Characteristics of patients with uncontrolled hypertension in the United States. N Engl J Med 2001, 345:479–486.
2. Hansson L, Zanchetti A, Carruthers SG, et al.: Effects of intensive blood-pressure lowering and low-dose aspirin in patients with hypertension: principal results of the Hypertension Optimal Treatment (HOT) randomized trial. Lancet 1998, 351:1755–1762. In this important study, the authors aggressively pursue goal diastolic blood pressures of 90, 85, and 80 mm Hg. In so doing, they provide convincing data regarding the necessity of combination therapy in most hypertensive patients.
3. BakrisGL: Maximizing cardiorenal benefit in the management of hypertension: achieve blood pressure goals. J Clin Hypertens 1999, 1:141–147.
4. Systolic Hypertension in the Elderly Program (SHEP) Cooperative Research Group. Prevention of stroke by antihypertensive drug treatment in older persons with isolated systolic hypertension: final results of SHEP. JAMA 1991, 265:3255–3264.
5. Dahlof B, Devereux RB, Kjeldsen SE, et al.: Cardiovascular morbidity and mortality in the Losartan Intervention For Endpoint reduction in hypertension study (LIFE): a randomized trial against atenolol. Lancet 2002, 359:995–1003. This important study is among the first to aggressively pursue control of both systolic and diastolic blood pressure. To achieve treatment goals, combination therapy was needed in more than 90% of patients.
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