Hypothalamic Ion Channels in Hypertension
Author:
Funder
Portuguese Foundation for Science and Technology
Publisher
Springer Science and Business Media LLC
Subject
Internal Medicine
Link
http://link.springer.com/article/10.1007/s11906-018-0814-x/fulltext.html
Reference103 articles.
1. Grassi G, Mark A, Esler M. The sympathetic nervous system alterations in human hypertension. Circ Res. 2015;116(6):976–90. https://doi.org/10.1161/CIRCRESAHA.116.303604 .
2. • Hwang AY, Dietrich E, Pepine CJ, Smith SM. Resistant Hypertension: Mechanisms and Treatment. Current Hypertension Reports. 2017;19(7):56. This review article summarize the multiple mechanisms, including the sympathetic nervous system that play an important role in development of treatment-resistant hypertension. https://doi.org/10.1007/s11906-017-0754-x .
3. Dibona GF. Sympathetic nervous system and hypertension. Hypertension 2013; 61(3), 556–560, https://doi.org/10.1161/HYPERTENSIONAHA.111.00633 .
4. •• Geraldes V, Gonçalves-Rosa N, Liu B, Paton JF, Rocha I. Chronic depression of hypothalamic paraventricular neuronal activity produces sustained hypotension in hypertensive rats. Exp Physiol. 2014;99(1):89–100. The study shows, for the first time, that overexpression of an inwardly rectifying potassium channel in the PVN provided a long-term antihypertensive response in conscious spontaneously hypertensive rats, supporting this area as a therapeutic target for the chronic control of blood pressure in neurogenic hypertension. https://doi.org/10.1113/expphysiol.2013.074823 .
5. •• Sonner PM, Lee S, Ryu PD, Lee SY, Stern JE. Imbalanced K+ and Ca2+ subthreshold interactions contribute to increased hypothalamic presympathetic neuronal excitability in hypertensive rats. J Physiol. 2011;589(3):667–83. The interplay between potassium and calcium channels biophysical properties influences PVN-RVLM pathway activity which may contribute to the characteristic sympathoexcitation observed in hypertension.
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