Progress and Future Aspects in Genetics of Human Hypertension
Author:
Publisher
Springer Science and Business Media LLC
Subject
Internal Medicine
Link
http://link.springer.com/content/pdf/10.1007/s11906-013-0388-6.pdf
Reference98 articles.
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2. Danaei G, Finucane MM, Lin JK, Singh GM, Paciorek CJ, Cowan MJ, et al. National, regional, and global trends in systolic blood pressure since 1980: systematic analysis of health examination surveys and epidemiological studies with 786 country-years and 5.4 million participants. Lancet. 2011;377:568–77.
3. Lopez AD, Mathers CD, Ezzati M, Jamison DT, Murray CJ. Global and regional burden of disease and risk factors, 2001: systematic analysis of population health data. Lancet. 2006;367:1747–57.
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5. •• Ehret GB, Munroe PB, Rice KM, Bochud M, Johnson AD, Chasman DI, et al. Genetic variants in novel pathways influence blood pressure and cardiovascular disease risk. Nature. 2011;478:103–9. To date, this is the largest meta-analysis of genome-wide association studies (GWAS) of the phenotypes of blood pressure by the International Consortium of Blood Pressure (ICBP). It included a discovery GWAS among 69,395 individuals and a combined sample of about 200,000 Europeans. It identified 16 novel loci associated with blood pressure. A genetic risk score calculated by GWAS significant variants was associated with hypertension, left ventricular wall thickness, stroke, and coronary artery disease.
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