Parasympathetic Vagal Control of Cardiac Function

Author:

Dyavanapalli Jhansi,Dergacheva Olga,Wang Xin,Mendelowitz David

Publisher

Springer Science and Business Media LLC

Subject

Internal Medicine

Reference62 articles.

1. Mastitskaya S, Marina N, Gourine A, Gilbey MP, Spyer KM, Teschemacher AG, et al. Cardioprotection evoked by remote ischaemic preconditioning is critically dependent on the activity of vagal pre-ganglionic neurones. Cardiovasc Res. 2012;95(4):487–94. doi: 10.1093/cvr/cvs212 . Gorine and colleagues found that increasing the activity of cholinergic vagal preganglionic neurons in the dorsal motor nucleus of the vagus (DMNX) protects left ventricular cardiomyocytes from ischemia/reperfusion injury while silencing DMNX neurons alters ventricular excitability, indicating parasympathetic activity to the heart can significantly alter electrical and mechanical function in the ventricles.

2. Kovach JA, Gottdiener JS, Verrier RL. Vagal modulation of epicardial coronary artery size in dogs. A two-dimensional intravascular ultrasound study. Circulation. 1995;92(8):2291–8.

3. Reid JV, Ito BR, Huang AH, Buffington CW, Feigl EO. Parasympathetic control of transmural coronary blood flow in dogs. Am J Physiol. 1985;249(2 Pt 2):H337–43.

4. Machhada A, Ang R, Ackland GL, Ninkina N, Buchman VL, Lythgoe MF, et al. Control of ventricular excitability by neurons of the dorsal motor nucleus of the vagus nerve. Heart Rhythm. 2015;12(11):2285–93. doi: 10.1016/j.hrthm.2015.06.005 . Gorine and colleagues found that increasing the activity of cholinergic vagal preganglionic neurons in the dorsal motor nucleus of the vagus (DMNX) protects left ventricular cardiomyocytes from ischemia/reperfusion injury while silencing DMNX neurons alters ventricular excitability, indicating parasympathetic activity to the heart can significantly alter electrical and mechanical function in the ventricles.

5. Ulphani JS, Cain JH, Inderyas F, Gordon D, Gikas PV, Shade G, et al. Quantitative analysis of parasympathetic innervation of the porcine heart. Heart Rhythm. 2010;7(8):1113–9. doi: 10.1016/j.hrthm.2010.03.043 .

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