Angiotensin-receptor blocking agents and the peroxisome proliferator-activated receptor-γ system
Author:
Publisher
Springer Science and Business Media LLC
Subject
Internal Medicine
Link
http://link.springer.com/content/pdf/10.1007/s11906-005-0019-y.pdf
Reference17 articles.
1. Benson SC, Pershadsingh HA, Ho CL, et al.: Identification of telmisartan as a unique angiotensin II receptor antagonist with selective PPAR-gamma-modulating activity. Hypertension 2004, 43:993–1002. The first paper to show structural similarity between telmisartan and the PPAR-gamma system, its effect on adipogenesis, and its ability to reduce metabolic dysfunction in rats with the metabolic syndrome.
2. Schupp M, Janke J, Clasen R, et al.: Angiotensin type 1 receptor blockers induce peroxisome proliferator-activated receptorgamma activity. Circulation 2004, 109:2054–2057. This study confirmed the effect of telmisartan and, to a lesser extent, irbesartan on adipocyte differentiation. Most importantly, by using an AT1 receptor-deficient model, they showed that the effect of ARB agents on PPAR-γ was independent of angiotensin II AT1 receptor binding.
3. Pershadsingh HA, Kurtz TW: Insulin-sensitizing effect of telmisartan. Diabetes Care 2004, 4:1015–1016.
4. Okada K, Hirano T, Ran J, Adachi M: Olmesartan medoxomil, an angiotensin II receptor blocker ameliorates insulin resistance and decreases triglyceride production in fructose-fed rats. Hypertens Res 2004, 27:293–299.
5. Derosa G, Cicero AF, Bertone G, et al.: Comparison of the effects of telmisartan and nifedipine gastrointestinal therapeutic system on blood pressure control, glucose metabolism, and the lipid profile in patients with type 2 diabetes mellitus and mild hypertension: a 12-month, randomized, double-blind study. Clin Ther 2004, 26:1228–1236.
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