Renin/prorenin-receptor biochemistry and functional significance
Author:
Publisher
Springer Science and Business Media LLC
Subject
Internal Medicine
Link
http://link.springer.com/content/pdf/10.1007/s11906-004-0088-3.pdf
Reference19 articles.
1. Nguyen G, Delarue F, Burckle C, et al.: Pivotal role of the renin/prorenin receptor in angiotensin II production and cellular responses to renin. J Clin Invest 2002, 109:1417–1427. This paper reports the cloning of a functional receptor of renin and describes the characteristics of renin binding (activation of MAP kinases, ERK1/2, and the co-factor activity of the receptor). The localization of the receptor on vascular smooth muscle cells and mesangial cells and its co-localization with renin are described.
2. Albitson AL, McDowall SG, Matsacos D, et al.: Evidence that the angiotensin IV (AT4) receptor is the enzyme insulin-regulated aminopeptidase. J Biol Chem 2001, 276:48623–48626.
3. Dzau VJ, Bernstein K, Celermajer D, et al.: The relevance of tissue angiotensin-converting enzyme: manifestations in mechanistic and endpoint data. Am J Cardiol 2001, 88(Suppl):1L-20L.
4. Schuijt MP, de Vries R, Saxena PR, et al.: Vasoconstriction is determined by interstitial rather than circulating angiotensin II. Br J Pharmacol 2002, 135:275–283.
5. Dell’Italia LJ, Meng QC, Balcells E, et al.: Compartimentalisation of angiotensin II generation in the dog heart: evidence for independent mechanisms in intravascular and interstitial space. J Clin Invest 1997, 100:253–258.
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