Targeting the Vasoprotective Axis of the Renin-Angiotensin System: A Novel Strategic Approach to Pulmonary Hypertensive Therapy
Author:
Publisher
Springer Science and Business Media LLC
Subject
Internal Medicine
Link
http://link.springer.com/content/pdf/10.1007/s11906-010-0122-6.pdf
Reference50 articles.
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3. Hamming I, Cooper ME, Haagmans BL, et al.: The emerging role of ACE2 in physiology and disease. J Pathol 2007, 212:1–11.
4. Donoghue M, Hsieh F, Baronas E, et al.: A novel angiotensin-converting enzyme-related carboxypeptidase (ACE2) converts angiotensin I to angiotensin 1–9. Circ Res 2000, 87:E1–E9.
5. •• Hong KH, Lee YJ, Lee E, et al.: Genetic ablation of the BMPR2 gene in pulmonary endothelium is sufficient to predispose to pulmonary arterial hypertension. Circulation 2008, 118:722–730. This study illustrates that pulmonary endothelial BMPRII deletion predisposes mice to PAH.
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