Therapeutic trials comparing angiotensin converting enzyme inhibitors and Angiotensin II receptor blockers
Author:
Publisher
Springer Science and Business Media LLC
Subject
Internal Medicine
Link
http://link.springer.com/content/pdf/10.1007/s11906-000-0045-8.pdf
Reference68 articles.
1. Effects of an angiotensin-converting-enzyme inhibitor, ramipril, on death from cardiovascular causes, myocardial infarction, and stroke in high-risk patients. The Heart Outcomes Prevention Evaluation (HOPE) Study Investigators. N Engl J Med 2000, 342:145–153. A clinical trial comparing ramipril with placebo in 9297 patients without heart failure, poor left ventricular function, or nephropathy who were older than 55 years of age, had known vascular disease and/ or diabetes, and had at least one other traditional risk factor. The 16% to 32% reduction seen with ramipril in almost every important cardiovascular endpoint was attributed by the authors to this specific ACE inhibitor rather than to the 3/2 mm Hg greater reduction in blood pressure. Some extrapolate these results to advocate an ACE inhibitor for all patients at high risk for cardiovascular events.
2. The SOLVD Investigators: Effect of enalapril on mortality and the development of heart failure in asymptomatic patients with reduced left ventricular ejection fractions. N Engl J Med 1992, 327:685–691.
3. Maschio G, Alberti D, Janin G, et al.: Effect of the angiotensinconverting enzyme inhibitor benazepril on the progression of chronic renal insufficiency. The Angiotensin-Converting Enzyme Inhibition in Progressive Renal Insufficiency Study Group. N Engl J Med 1996, 334:939–945.
4. Ruggenenti P, Perna A, Gherardi G, et al.: Renal function and requirement for dialysis in chronic nephropathy patients on long-term ramipril: REIN follow-up trial. Gruppo Italiano di Studi Epidemiologici in Nefrologia (GISEN). Ramipril Efficacy in Nephropathy. Lancet. 1998, 352:1252–1256.
5. Lewis EJ, Hunsicker LG, Bain RP, et al.: The effect of angiotensin converting enzyme inhibition in diabetic nephropathy. N Engl J Med 1993, 323:1456–1462.
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