Spironolactone in congestive heart failure
Author:
Publisher
Springer Science and Business Media LLC
Subject
Internal Medicine
Link
http://link.springer.com/content/pdf/10.1007/s11906-000-0027-x.pdf
Reference41 articles.
1. Gheorghiade M, Cody RJ, Francis GS, et al.: Current medical therapy for advanced heart failure. Am Heart J 1998, 132:S231-S248.
2. O‘Connor CM, Gattis WA, Swedberg K: Current and novel pharmacologic approaches in advanced heart failure. Am Heart J 1998, 135:S249-S263.
3. Pitt B, Zannad F, Remme WJ, et al.: The effect of spironolactone on morbidity and mortality in patients with severe heart failure. N Engl J Med 1999, 341:709–717. The RALES trial demonstrates a 30% reduction in total mortality among patients receiving low-dose spironolactone. This lower risk was attributed to both a reduction in progressive heart failure and sudden cardiac death. Hospitalization for worsening heart failure was also significantly decreased in the spironolactone group.
4. MacFadyen RJ, Barr CS, Struthers AD: Aldosterone blockade reduces vascular collagen turnover, improves heart rate variability and reduces early morning rise in heart rate in heart failure patients. Cardiovasc Res 1997, 35:30–34. This article presents the first human data demonstrating that spironolactone, added to ACE inhibitor treatment, improves heart rate variability and reduces myocardial collagen turnover.
5. Zannad F: Angiotensin-converting enzyme inhibitor and spironolactone combination therapy. New objectives in congestive heart failure treatment. Am J Cardiol 1993, 71:34A-39A.
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