Sensitivity of a two-dimensional biomorphoelastic model for post-burn contraction

Author:

Egberts GingerORCID,Desmoulière AlexisORCID,Vermolen FredORCID,van Zuijlen PaulORCID

Abstract

AbstractWe consider a two-dimensional biomorphoelastic model describing post-burn scar contraction. This model describes skin displacement and the development of the effective Eulerian strain in the tissue. Besides these mechanical components, signaling molecules, fibroblasts, myofibroblasts, and collagen also play a significant role in the model. We perform a sensitivity analysis for the independent parameters of the model and focus on the effects on features of the relative surface area and the total strain energy density. We conclude that the most sensitive parameters are the Poisson’s ratio, the equilibrium collagen concentration, the contraction inhibitor constant, and the myofibroblast apoptosis rate. Next to these insights, we perform a sensitivity analysis where the proliferation rates of fibroblasts and myofibroblasts are not the same. The impact of this model adaptation is significant.

Funder

Nederlandse Brandwonden Stichting

Publisher

Springer Science and Business Media LLC

Subject

Mechanical Engineering,Modeling and Simulation,Biotechnology

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