Abstract
AbstractWe present a novel patient-specific fluid-solid-growth framework to model the mechanobiological state of clinically detected intracranial aneurysms (IAs) and their evolution. The artery and IA sac are modeled as thick-walled, non-linear elastic fiber-reinforced composites. We represent the undulation distribution of collagen fibers: the adventitia of the healthy artery is modeled as a protective sheath whereas the aneurysm sac is modeled to bear load within physiological range of pressures. Initially, we assume the detected IA is stable and then consider two flow-related mechanisms to drive enlargement: (1) low wall shear stress; (2) dysfunctional endothelium which is associated with regions of high oscillatory flow. Localized collagen degradation and remodelling gives rise to formation of secondary blebs on the aneurysm dome. Restabilization of blebs is achieved by remodelling of the homeostatic collagen fiber stretch distribution. This integrative mechanobiological modelling workflow provides a step towards a personalized risk-assessment and treatment of clinically detected IAs.
Funder
Schweizerischer Nationalfonds zur Förderung der Wissenschaftlichen Forschung
Engineering and Physical Sciences Research Council
Publisher
Springer Science and Business Media LLC
Subject
Mechanical Engineering,Modelling and Simulation,Biotechnology
Reference82 articles.
1. Aparício PJF (2016) Modelling signalling pathways and cellular dynamics in vascular mechanobiology: a theoretical, experimental and computational study. PhD thesis, Department of Engineering Science, University of Oxford
2. Aparício P, Mandaltsi A, Boamah J, Chen H, Selimovic A, Bratby M, Uberoi R, Ventikos Y, Watton PN (2014) Modelling the influence of endothelial cell heterogeneity on abdominal aneurysm evolution: a patient-specific simulation using a novel fluid-solid-growth framework. Int J Numer Methods Biomed Eng 30:563–586
3. Aparício P, Thompson MS, Watton PN (2016) A novel chemo-mechano-biological model of arterial tissue growth and remodelling. J Biomech 49:2321–2330
4. Babu AR, Byju AG, Gundiah N (2015) Biomechanical properties of human ascending thoracic aortic dissections. J Biomech Eng 137(8):081013
5. Balay S, Gropp WD, McInnes LC, Smith BF (1997) Efficient management of parallelism in object oriented numerical software libraries. In: Arge E, Bruaset AM, Langtangen HP (eds) Modern software tools in scientific computing. Birkhäuser Press, Basel, pp 163–202
Cited by
9 articles.
订阅此论文施引文献
订阅此论文施引文献,注册后可以免费订阅5篇论文的施引文献,订阅后可以查看论文全部施引文献