Concurrent allopurinol and 5-fluorouracil: 5-fluoro-2?-deoxyuridylate formation and thymidylate synthase inhibition in rat colon carcinoma and in regenerating rat liver

Author:

Berne M.,Gustavsson B.,Almersj� O.,Spears C. P.,Waldenstr�m J.

Publisher

Springer Science and Business Media LLC

Subject

Pharmacology (medical),Cancer Research,Pharmacology,Toxicology,Oncology

Reference30 articles.

1. Barth O, Maass H (1970) Verhalten von Enzymaktivitäten, speziell der Thymidylate-Synthetase, nach Hepatectomie und deren Beeinflußbarkeit durch Trenimon und Aktinomycin. Z Krebstforsch 75: 45

2. Berger SH, Clark J, Kabus D, Berger G (1986) Thymidylate synthase, enzyme, mRNA and structural gene variation in human colonic cell lines and tumors. Proc AACR 27, March Abstr 1181

3. Berne MHO, Gustavsson BG, Almersjö O, Spears CP (1986) Sequential methotrexate/5-FU:FdUMP formation and TS inhibition in a transplantable rodent colon adenocarcinoma. Cancer Chemother Pharmacol 16: 237

4. Berne MHO, Gustavsson B, Almersjö O, Spears CP, Waldenström J (1987) Thymidylate synthase inhibition by 5-fluorouracil in normal and regenerating rat liver. Cancer Lett (in press)

5. Chabner B (1982) Pyrimidine antagonists. In: Pharmacological principles of cancer treatment. Saunders, Philadelphia, p 183

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