Association Between Automated 3D Measurement of Coronary Luminal Narrowing and Risk of Future Myocardial Infarction

Author:

Candreva AlessandroORCID,Lodi Rizzini Maurizio,Calò Karol,Pagnoni Mattia,Munhoz Daniel,Chiastra Claudio,Aben Jean-Paul,Fournier Stephane,Muller Olivier,De Bruyne Bernard,Collet Carlos,Gallo Diego,Morbiducci Umberto

Abstract

AbstractThis study focuses on identifying anatomical markers with predictive capacity for long-term myocardial infarction (MI) in focal coronary artery disease (CAD). Eighty future culprit lesions (FCL) and 108 non-culprit lesions (NCL) from 80 patients underwent 3D quantitative coronary angiography. The minimum lumen area (MLA), minimum lumen ratio (MLR), and vessel fractional flow reserve (vFFR) were evaluated. MLR was defined as the ratio between MLA and the cross-sectional area at the proximal lesion edge, with lower values indicating more abrupt luminal narrowing. Significant differences were observed between FCL and NCL in MLR (0.41 vs. 0.53, p < 0.001). MLR correlated inversely with translesional vFFR (r =  − 0.26, p = 0.0004) and was the strongest predictor of MI at 5 years (AUC = 0.75). Lesions with MLR < 0.40 had a fourfold increased MI incidence at 5 years. MLR is a robust predictor of future adverse coronary events. Graphical Abstract The minimum lumen ratio (MLR) is defined as the ratio between the minimum lumen area (MLA) and the cross-sectional area at the proximal edge of the lesion (PROXA). A lower MLR suggests a more pronounced luminal narrowing upstream of the MLA. This specific anatomical lesion characteristic correlates with higher translesional pressure gradients and has been found to be highly predictive of lesion destabilization over a 5-year period. Notably, lesions exhibiting MLR values below 0.399 were associated with a fourfold increase in the incidence of myocardial infarction (MI) within the same timeframe.

Funder

Politecnico di Torino

Publisher

Springer Science and Business Media LLC

同舟云学术

1.学者识别学者识别

2.学术分析学术分析

3.人才评估人才评估

"同舟云学术"是以全球学者为主线,采集、加工和组织学术论文而形成的新型学术文献查询和分析系统,可以对全球学者进行文献检索和人才价值评估。用户可以通过关注某些学科领域的顶尖人物而持续追踪该领域的学科进展和研究前沿。经过近期的数据扩容,当前同舟云学术共收录了国内外主流学术期刊6万余种,收集的期刊论文及会议论文总量共计约1.5亿篇,并以每天添加12000余篇中外论文的速度递增。我们也可以为用户提供个性化、定制化的学者数据。欢迎来电咨询!咨询电话:010-8811{复制后删除}0370

www.globalauthorid.com

TOP

Copyright © 2019-2024 北京同舟云网络信息技术有限公司
京公网安备11010802033243号  京ICP备18003416号-3