Biomechanical Impact of Pathogenic MYBPC3 Truncation Variant Revealed by Dynamically Tuning In Vitro Afterload-Reference-Cited by-同舟云学术

Biomechanical Impact of Pathogenic MYBPC3 Truncation Variant Revealed by Dynamically Tuning In Vitro Afterload

Published:2023-03-06 Issue:4 Volume:16 Page:828-841
ISSN:1937-5387
Container-title:Journal of Cardiovascular Translational Research
language:en
Short-container-title:J. of Cardiovasc. Trans. Res.

Author:

Ramachandran Abhinay,Livingston Carissa E.,Vite Alexia,Corbin Elise A.,Bennett Alexander I.,Turner Kevin T.,Lee Benjamin W.,Lam Chi Keung,Wu Joseph C.,Margulies Kenneth B.^ORCID

Funder

National Center for Advancing Translational Sciences

Sidney Pestka M’61 Term Fellowship

National Institutes of Health

American Heart Association

National Heart, Lung, and Blood Institute

National Center for Science and Engineering Statistics

Provost Postdoctoral Fellowship

Fondation Leducq

Gordon and Llura Gund Family Fund

Publisher

Springer Science and Business Media LLC

Subject

Genetics (clinical),Cardiology and Cardiovascular Medicine,Pharmaceutical Science,Genetics,Molecular Medicine

Link

https://link.springer.com/content/pdf/10.1007/s12265-022-10348-4.pdf

Reference33 articles.

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3. Toepfer CN, Wakimoto H, Garfinkel AC, et al. Hypertrophic cardiomyopathy mutations in MYBPC3 dysregulate myosin. Sci Trans Med. 2019;11(476):eaat1199. https://doi.org/10.1126/scitranslmed.aat1199.

4. Davis J, Davis LC, Correll RN, et al. A tension-based model distinguishes hypertrophic versus dilated cardiomyopathy. Cell. 2016;165(5):1147–59. https://doi.org/10.1016/j.cell.2016.04.002.

5. Green EM, Wakimoto H, Anderson RL, et al. Heart disease: a small-molecule inhibitor of sarcomere contractility suppresses hypertrophic cardiomyopathy in mice. Science. 2016;351(6273):617–21. https://doi.org/10.1126/science.aad3456.

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