Safety, Mortality, and Hemodynamic Impact of Patients with MitraClip Undergoing Left Ventricular Assist Device Implantation
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Published:2021-10-28
Issue:
Volume:
Page:
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ISSN:1937-5387
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Container-title:Journal of Cardiovascular Translational Research
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language:en
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Short-container-title:J. of Cardiovasc. Trans. Res.
Author:
Fox HenrikORCID, Gyoten Takayuki, Rojas Sebastian V., Deutsch Marcus-André, Schramm René, Rudolph Volker, Gummert Jan F., Morshuis Michiel
Abstract
AbstractThe interactions and hemodynamic impact of transcatheter percutaneous mitral valve repair (TMR) have not yet been investigated in patients undergoing left ventricular assist device (LVAD) implantation, but hemodynamic adverse effects are feared in the combination of TMR and LVAD for altered mitral valve flow. This study investigated the hemodynamic interplay in combination of TMR and LVAD in 119 patients, and propensity score match analysis revealed no difference in both perioperative mortality and 2-year follow-up survival (p = 0.84). Nonetheless, postoperatively mean pulmonary arterial pressure, pulmonary capillary wedge pressure, and cardiac index improved, and multivariable cox regression analysis at 2 years identified preoperative total bilirubin and temporary right ventricular mechanical circulatory support as independent risk factors for all-cause mortality but not TMR. Prior TMR has no impact on mortality or cardiovascular complications in patients with LVAD.
Graphical abstract
Funder
Krankenhausbetriebsgesellschaft Bad Oeynhausen mbH
Publisher
Springer Science and Business Media LLC
Subject
Genetics (clinical),Cardiology and Cardiovascular Medicine,Pharmaceutical Science,Genetics,Molecular Medicine
Reference23 articles.
1. Goliasch, G., Bartko, P. E., Pavo, N., Neuhold, S., Wurm, R., Mascherbauer, J., Lang, I. M., Strunk, G., & Hulsmann, M. (2018). Refining the prognostic impact of functional mitral regurgitation in chronic heart failure. European Heart Journal, 39(1), 39–46. https://doi.org/10.1093/eurheartj/ehx402 2. Coats, A. J. S., Anker, S. D., Baumbach, A., Alfieri, O., von Bardeleben, R. S., Bauersachs, J., Bax, J. J., Boveda, S., Celutkiene, J., Cleland, J. G., Dagres, N., Deneke, T., Farmakis, D., Filippatos, G., Hausleiter, J., Hindricks, G., Jankowska, E. A., Lainscak, M., Leclercq, C., … Prendergast, B. (2021). The management of secondary mitral regurgitation in patients with heart failure: A joint position statement from the Heart Failure Association (HFA), European Association of Cardiovascular Imaging (EACVI), European Heart Rhythm Association (EHRA), and European Association of Percutaneous Cardiovascular Interventions (EAPCI) of the ESC. European Heart Journal. https://doi.org/10.1093/eurheartj/ehab086 3. Friedrichs, K., & Rudolph, V. (2019). MITRA-FR and COAPT: Why are the results so different and what are the consequences for the daily routine? Herz, 44(7), 592–595. https://doi.org/10.1007/s00059-019-04844-8 4. Stone, G. W., Lindenfeld, J., Abraham, W. T., Kar, S., Lim, D. S., Mishell, J. M., Whisenant, B., Grayburn, P. A., Rinaldi, M., Kapadia, S. R., Rajagopal, V., Sarembock, I. J., Brieke, A., Marx, S. O., Cohen, D. J., Weissman, N. J., Mack, M. J., & Investigators, C. (2018). Transcatheter mitral-valve repair in patients with heart failure. New England Journal of Medicine, 379(24), 2307–2318. https://doi.org/10.1056/NEJMoa1806640 5. Kreusser, M. M., Hamed, S., Weber, A., Schmack, B., Volz, M. J., Geis, N. A., Grossekettler, L., Pleger, S. T., Ruhparwar, A., Katus, H. A., & Raake, P. W. (2020). MitraClip implantation followed by insertion of a left ventricular assist device in patients with advanced heart failure. ESC Heart Fail. https://doi.org/10.1002/ehf2.12982
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