Downregulation of the Complement Cascade In Vitro, in Mice and in Patients with Cardiovascular Disease by the BET Protein Inhibitor Apabetalone (RVX-208)
Author:
Funder
Resverlogix Corp
Publisher
Springer Science and Business Media LLC
Subject
Genetics (clinical),Cardiology and Cardiovascular Medicine,Pharmaceutical Science,Genetics,Molecular Medicine
Link
http://link.springer.com/article/10.1007/s12265-017-9755-z/fulltext.html
Reference52 articles.
1. Merle, N. S., Church, S. E., Fremeaux-Bacchi, V., & Roumenina, L. T. (2015). Complement system part I—molecular mechanisms of activation and regulation. Frontiers in Immunology, 6, 262. doi: 10.3389/fimmu.2015.00262 .
2. Amara, U., Flierl, M. A., Rittirsch, D., Klos, A., Chen, H., Acker, B., et al. (2010). Molecular intercommunication between the complement and coagulation systems. Journal of Immunology, 185(9), 5628–5636. doi: 10.4049/jimmunol.0903678 .
3. Carter, A. M. (2012). Complement activation: an emerging player in the pathogenesis of cardiovascular disease. Scientifica (Cairo), 2012, 402783. doi: 10.6064/2012/402783 .
4. Hertle, E., Stehouwer, C. D., & van Greevenbroek, M. M. (2014). The complement system in human cardiometabolic disease. [Research Support, Non-U.S. Gov'tReview]. Molecular Immunology, 61(2), 135–148. doi: 10.1016/j.molimm.2014.06.031 .
5. McLure, K. G., Gesner, E. M., Tsujikawa, L., Kharenko, O. A., Attwell, S., Campeau, E., et al. (2013). RVX-208, an inducer of ApoA-I in humans, is a BET bromodomain antagonist. PloS One, 8(12), e83190. doi: 10.1371/journal.pone.0083190 .
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