Reference values of EORTC QLQ-C30, EORTC QLQ-BR23, and EQ-5D-5L for women with non-metastatic breast cancer at diagnosis and 2 years after
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Published:2023-01-11
Issue:4
Volume:32
Page:989-1003
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ISSN:0962-9343
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Container-title:Quality of Life Research
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language:en
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Short-container-title:Qual Life Res
Author:
Miret CarmeORCID, Orive MirenORCID, Sala MariaORCID, García-Gutiérrez SusanaORCID, Sarasqueta CristinaORCID, Legarreta Maria JoseORCID, Redondo MaximinoORCID, Rivero AmadoORCID, Castells XavierORCID, Quintana José M.ORCID, Garin OlatzORCID, Ferrer MontseORCID, Comas Mercè, Domingo Laia, Macià Francesc, Roman Marta, Romero Anabel, Barata Teresa, Diez de la Lastra Isabel, de la Vega Mariola, Bare Marisa, Torà Núria, Ferrer Joana, Castanyer Francesc, Carmona Carmen, García Susana, Martín Maximina, Gonzalez Nerea, Valverde Maria Amparo, Saez Alberto, Barredo Inma, de Toro Manuel, Ferreiro Josefa, Pérez Jeanette, Valcárcel Cristina, Padilla María del Carmen, Téllez Teresa, Zarcos Irene, Churruca Cristina, Perales Amaia, Recio Javier, Ruiz Irune, Urraca Jose María, Michelena MªJesús, Moreno Julio, Mallabiabarrena Gaizka, Cobos Patricia, Otero Borja, Gorostiaga Javier, Troya Itsaso,
Abstract
Abstract
Purpose
To obtain reference norms of EORTC QLQ-C30, EORTC QLQ-BR23, and EQ-5D-5L, based on a population of Spanish non-metastatic breast cancer patients at diagnosis and 2 years after, according to relevant demographic and clinical characteristics.
Methods
Multicentric prospective cohort study including consecutive women aged ≥ 18 years with a diagnosis of incident non-metastatic breast cancer from April 2013 to May 2015. Health-related quality of life (HRQoL) questionnaires were administered between diagnosis and beginning the therapy, and 2 years after. HRQoL differences according to age, comorbidity and stage were tested with ANOVA or Chi Square test and multivariate linear regression models.
Results
1276 patients were included, with a mean age of 58 years. Multivariate models of EORTC QLQ-C30 summary score and EQ-5D-5L index at diagnosis and at 2-year follow-up show the independent association of comorbidity and tumor stage with HRQoL. The standardized multivariate regression coefficient of EORTC QLQ-C30 summary score was lower (poorer HRQoL) for women with stage II and III than for those with stage 0 at diagnosis (− 0.11 and − 0.07, p < 0.05) and follow-up (− 0.15 and − 0.10, p < 0.01). The EQ-5D-5L index indicated poorer HRQoL for women with Charlson comorbidity index ≥ 2 than comorbidity 0 both at diagnosis (− 0.13, p < 0.001) and follow-up (− 0.18, p < 0.001). Therefore, we provided the reference norms at diagnosis and at the 2-year follow-up, stratified by age, comorbidity index, and tumor stage.
Conclusion
These HRQoL reference norms can be useful to interpret the scores of women with non-metastatic breast cancer, comparing them with country-specific reference values for this population.
Funder
Instituto de Salud Carlos III Osasun Saila, Eusko Jaurlaritzako Agència de Gestió d'Ajuts Universitaris i de Recerca Universitat Pompeu Fabra
Publisher
Springer Science and Business Media LLC
Subject
Public Health, Environmental and Occupational Health
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