Abstract
Abstract
Purpose
This study aimed to develop a Japanese value set for the EORTC QLU-C10D, a multi-attribute utility measure derived from the cancer-specific health-related quality-of-life (HRQL) questionnaire, the EORTC QLQ-C30. The QLU-C10D contains ten HRQL dimensions: physical, role, social and emotional functioning, pain, fatigue, sleep, appetite, nausea, and bowel problems.
Methods
Quota sampling of a Japanese online panel was used to achieve representativeness of the Japanese general population by sex and age (≥ 18 years). The valuation method was an online discrete choice experiment. Each participant considered 16 choice pairs, randomly assigned from 960 choice pairs. Each pair included two QLU-C10D health states and life expectancy. Data were analyzed using conditional logistic regression, parameterized to fit the quality-adjusted life-year framework. Preference weights were calculated as the ratio of each dimension-level coefficient to the coefficient for life expectancy.
Results
A total of 2809 eligible panel members consented, 2662/2809 (95%) completed at least one choice pair, and 2435/2662 (91%) completed all choice pairs. Within dimensions, preference weights were generally monotonic. Physical functioning, role functioning, and pain were associated with the largest utility weights. Intermediate utility weights were associated with social functioning and nausea; the remaining symptoms and emotional functioning were associated with smaller utility decrements. The value of the worst health state was − 0.221, lower than that seen in most other existing QLU-C10D country-specific value sets.
Conclusions
The Japan-specific QLU-C10D value set is suitable for evaluating the cost and utility of oncology treatments for Japanese health technology assessment and decision-making.
Funder
Japanese National Institute of Public Health
National Health and Medical Research Council
Publisher
Springer Science and Business Media LLC
Reference53 articles.
1. National Institute for Health and Care Excellence. 2013 NICE Process and Methods Guides. Guide to the Methods of Technology Appraisal 2013. London: National Institute for Health and Care Excellence (NICE).
2. Shiroiwa, T. (2020). Cost-effectiveness evaluation for pricing medicines and devices: A new value-based price adjustment system in Japan. International journal of technology assessment in health care, 36(3), 270–276.
3. Center for Outcomes Research and Economic Evaluation for Health. 2022 Guideline for Preparing Cost-Effectiveness Evaluation to the Central Social Insurance Medical Council. Available from https://c2h.niph.go.jp/tools/guideline/guideline_en.pdf. accessed 10 Jan 2023
4. 1990 EuroQol--a new facility for the measurement of health-related quality of life. Health policy (Amsterdam, Netherlands). 16(3):199–208
5. Shiroiwa, T., Fukuda, T., Ikeda, S., et al. (2016). Japanese population norms for preference-based measures: EQ-5D-3L, EQ-5D-5L, and SF-6D. Quality of life Research, 25(3), 707–719.
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