Evolution of frustrated and stabilising contacts in reconstructed ancient proteins

Author:

Crippa MartinaORCID,Andreghetti Damiano,Capelli RiccardoORCID,Tiana GuidoORCID

Abstract

AbstractEnergetic properties of a protein are a major determinant of its evolutionary fitness. Using a reconstruction algorithm, dating the reconstructed proteins and calculating the interaction network between their amino acids through a coevolutionary approach, we studied how the interactions that stabilise 890 proteins, belonging to five families, evolved for billions of years. In particular, we focused our attention on the network of most strongly attractive contacts and on that of poorly optimised, frustrated contacts. Our results support the idea that the cluster of most attractive interactions extends its size along evolutionary time, but from the data, we cannot conclude that protein stability or that the degree of frustration tends always to decrease.

Funder

Università degli Studi di Milano

Publisher

Springer Science and Business Media LLC

Subject

General Medicine,Biophysics

Cited by 1 articles. 订阅此论文施引文献 订阅此论文施引文献,注册后可以免费订阅5篇论文的施引文献,订阅后可以查看论文全部施引文献

1. Protein Stability: Enhancement and Measurement;Methods in Molecular Biology;2023

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