Update on the management of the pregnant patient with antiphospholipid antibody

Author:

Sammaritano Lisa R.

Publisher

Springer Science and Business Media LLC

Subject

Rheumatology

Reference56 articles.

1. Wilson WA, Gharavi AE, Koike T, et al.: International consensus statement on preliminary classification criteria for definite antiphospholipid syndrome. Arthritis Rheum 1999, 42:1309–1311. The first published criteria for antiphospholipid syndrome, formulated at the 8th International Symposium on Antiphospholipid Antibodies in Sapporo, Japan, 1998.

2. Branch DW, Silver R, Pierangeli S, van Leeuwen I, Harris EN: Antiphospholipid antibodies other than lupus anticoagulant and anticardiolipin antibodies in women with recurrent pregnancy loss, fertile controls, and antiphospholipid syndrome. Obstet Gynecol 1997, 89:549–555. Serum antibody binding against six phospholipids (cardiolipin, phosphatidic acid, phosphatidylserine, phosphatidylcholine, phosphatidylinosital, and phosphatidylethanolamine) was evaluated in three groups of women: 147 women with recurrent pregnancy loss negative for anticardiolipin antibody (aCL) and lupus anticoagulant (LA), 104 healthy controls, and 43 women with well-characterized antiphospholipid syndrome. Women with recurrent pregnancy loss were no more likely than fertile controls to have elevated levels of antiphospholipid antibodies once aCL and LA were excluded. Testing for antiphosphospholipid antibodies other than LA and aCL is not clinically useful in the evaluation of recurrent pregnancy loss.

3. Parke AL, Wilson D, Maier D: The prevalence of antiphospholipid antibodies in women with recurrent spontaneous abortion, women with successful pregnancies, and women who have never been pregnant. Arthritis Rheum 1991, 34:1231–1235.

4. McNeil HP, Simpson RJ, Chesterman CN, Krilis SA: Antiphospholipid antibodies are directed against a complex antigen that includes a lipid-binding inhibitor of coagulation: beta 2-glycoprotein I (apolipoprotein H). Proc Natl Acad Sci USA 1990, 87:4120–4125.

5. Galli M: Should we include anti-prothrombin antibodies in the screening for the antiphospholipid syndrome? J Autommunity 2000, 15:101–106.

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