Polyarteritis nodosa and microscopic polyangiitis: Etiologic and diagnostic considerations

Author:

Hughes Laura B.,Bridges S. Louis

Publisher

Springer Science and Business Media LLC

Subject

Rheumatology

Reference79 articles.

1. Kussmaul A, Maier R: Ueber eine bisher nicht beschriebene eigenthümliche Arterienerkrankung, die mit Morbus Brightü und rapid fortschreitender allgemeiner Muskellähmung einhergeht. Dtsch Arch Klin Med 1866, 1:484–518.

2. Davson J, Ball J, Platt R: The kidney in polyarteritis nodosa. Q J Med 1948, 17:175–202.

3. Wainwright J, Davson J: The renal appearances in microscopic form of polyarteritis nodosa. J Pathol Bacteriol 1950, 62:189–196.

4. Lightfoot RW Jr, Michel BA, Bloch DA, et al.: The American College of Rheumatology 1990 criteria for the classification of polyarteritis nodosa. Arthritis Rheum 1990, 33:1088–1093. This report describes the ACR criteria for the classification of polyarteritis nodosa. These criteria were developed by comparing 118 patients with PAN with 689 patients with other forms of vasculitis. Ten criteria were selected for evaluation. The presence of three or more of these 10 criteria was associated with a sensitivity of 82.2% and specificity of 86.6%.

5. Jennette JC, Falk RJ, Andrassy K, et al.: Nomenclature of systemic vasculitides. Proposal of an international consensus conference. Arthritis Rheum 1994, 37:187–192. This article delineates the conclusions and proposals made at the Chapel Hill Consensus Conference on the Nomenclature of Systemic Vasculitis. In this classification, polyarteritis nodosa (or alternatively classic polyarteritis nodosa) is restricted to disease in which there is arteritis in medium-sized and small arteries without involvement of smaller vessels. Therefore, patients with vasculitis affecting arterioles, venules, or capillaries, including glomerular capillaries, are excluded from this diagnostic category. The term “microscopic polyangiitis” (or alternatively “microscopic polyarteritis”) connotes pauci-immune necrotizing vasculitis affecting small vessels, with or without involvement of medium-sized arteries. Cryoglobulinemic vasculitis, Henoch-Schönlein purpura, and other forms of immune complex-mediated small vessel vasculitis must be ruled out to make this diagnosis.

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