Epidemiology of the rheumatic diseases of childhood

Author:

Manners Prudence J.

Publisher

Springer Science and Business Media LLC

Subject

Rheumatology

Reference36 articles.

1. Thomson W, Donn RP: Juvenile idiopathic arthritis genetics: what’s new, what’s next? Arthritis Res 2002, 4:302–306. This provides an excellent overview of genetic epidemiology, providing perspective on a difficult subject appropriate to clinicians, and highlighting an area of increasing importance in the future study of JIA.

2. Thomson W, Barrett JH, Donn RP, et al.: Juvenile idiopathic arthritis classified by the ILAR criteria: HLA associations in UK patients. Rheumatology (Oxford) 2002, 41:1183–1189. This study is one of the first to provide substantial evidence that the International League of Associations for Rheumatology subgroups of JIA have some genetic basis for their differences, though the evidence is not uniformly strong throughout the subgroups. Risk factors for disease can be better defined if the genetic component of JIA can be identified as an essential part of the epidemiology of disease.

3. Zeggini E, Thomson W, Alansari A, et al.: Development of tumor necrosis factor (TNF) polymorphism genotyping and association study with juvenile idiopathic arthritis (JIA) [abstract]. Rheumatology (Oxford) 2002, 41:1–3. This article deals with a large patient cohort. There will be many such studies reported and many such studies are needed to obtain a useful picture.

4. Date Y, Seki N, Kamizono S, et al.: Identification of a genetic risk factor for systemic juvenile rheumatoid arthritis in the 5’-flanking region of the TNF-alpha gene and HLA genes. Arthritis Rheum 1999, 42:2577–2582. Systemic arthritis has been considered to have a different response to anti-TNF-alpha therapy to the other subgroups of JIA, according to several reports. Therefore, it is relevant that this subgroup of JIA receive close attention regarding cytokines and genetic profiles.

5. Ozen S, Alikasifoglu M, Bakkaloglu A, et al.: Tumor necrosis factor alpha G-A-238 and G-A-308 polymorphisms in juvenile idiopathic arthritis. Rheumatology (Oxford) 2002, 41:223–227.

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