Abstract
Abstract
Purpose of Review
Heart failure (HF) is commonly associated with iron deficiency (ID), defined as insufficient levels of iron to meet physiological demands. ID’s association with anaemia is well understood but it is increasingly recognised as an important comorbidity in HF, even in the absence of anaemia. This review summarises contemporary evidence for the measurement and treatment of ID, in both HFrEF and HFpEF, and specific HF aetiologies, and highlights important gaps in the evidence-base.
Recent Findings
ID is common among patients with HF and associated with increased morbidity and mortality. Correcting ID in patients with HF can impact upon functional status, exercise tolerance, symptoms, and overall quality of life, irrespective of anaemia status.
Summary
ID is a modifiable comorbidity in HF. Therefore, recognising and treating ID has emerging therapeutic potential and is important for all clinicians who care for patients with HF to understand the rationale and approach to treatment.
Publisher
Springer Science and Business Media LLC
Subject
Cardiology and Cardiovascular Medicine
Reference88 articles.
1. Hooda J, Shah A, Zhang L. Heme, an essential nutrient from dietary proteins, critically impacts diverse physiological and pathological processes. Nutr 2014, Vol 6, Pages 1080–1102 [Internet]. 2014 [cited 2023 Apr 12];6(3):1080–102. Available from: https://www.mdpi.com/2072-6643/6/3/1080/htm.
2. Ems T, Lucia KS, Huecker MR. Biochemistry, iron absorption. StatPearls [Internet]. 2022 [cited 2022 Nov 26]; Available from: https://www.ncbi.nlm.nih.gov/books/NBK448204/.
3. West AR, Oates PS. Mechanisms of heme iron absorption: Current questions and controversies. World J Gastroenterol [Internet]. 2008 Jul 7 [cited 2023 Apr 12];14(26):4101. Available from: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2725368/.
4. Yuen H-W, Gossman WG. Iron toxicity. StatPearls [Internet]. 2022 [cited 2022 Nov 26]; Available from: https://www.ncbi.nlm.nih.gov/books/NBK459224/.
5. Dattani A. Iron therapy in heart failure – the evidence so far [Internet]. British Cardiovascular Society. 2021 [cited 2022 Jul 24]. Available from: https://www.britishcardiovascularsociety.org/resources/editorials/articles/iron-therapy-heart-failure-evidence-so-far.
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