Bridging Anticoagulation with Mechanical Heart Valves: Current Guidelines and Clinical Decisions

Author:

Ali Mahboob,Becker Richard C.ORCID

Publisher

Springer Science and Business Media LLC

Subject

Cardiology and Cardiovascular Medicine

Reference24 articles.

1. Nkomo VT, Gardin JM, Skelton TN, Gottdiener JS, Scott CG, Enriquez-Sarano M. Burden of valvular heart diseases: a population-based study. Lancet (London, England). 2006;368(9540):1005–11.

2. Rezzoug N, Vaes B, de Meester C, Degryse J, Van Pottelbergh G, Mathei C, et al. The clinical impact of valvular heart disease in a population-based cohort of subjects aged 80 and older. BMC Cardiovasc Disord. 2016;16(1):7–10.

3. • Lung B, Delgado V, Rosenhek R, Price S, Prendergast B, Wendler O, De Bonis M, Tribouilloy C, Evangelista A, Bogachev-Prokophiev A, Apor A, Ince H, Laroche C, Popescu BA, Piérard L, et al. Contemporary Presentation and Management of Valvular Heart Disease: The EURObservational Research Programme Valvular Heart Disease II Survey. Circulation. 2019; 140 (14):1156–1169. A prospective registry of 7247 patients with valvular heart disease. Management according to class I recommendations showed high concordance among patients with aortic, but not mitral valvular heart disease. The large infrastructure is an option to determine the management of patients with mechanical heart valves requiring interruption of anticoagulant therapy for surgery.

4. •• Eikelboom JW, Connolly SJ, Brueckmann M, Granger CB, Kappetein AP, Mack MJ, et al. Dabigatran versus warfarin in patients with mechanical heart valves. N Engl J Med. 2013;369:1206–14 The first randomized clinical trial of warfarin versus dabigatran in patients with mechanical heart valves. The study was stopped by the Data and Safety Monitoring Committee because of higher mortality, thrombosis and bleeding events among participants receiving dabigatran.

5. Carrel TP, Klingenmann W, Mohacsi PJ, Berdat P, Althaus U. Perioperative bleeding and thromboembolic risk during non-cardiac surgery in patients with mechanical prosthetic heart valves: an institutional review. J Heart Valve Dis. 1999;8(4):392–8.

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