Genetic Engineering of Donor Pig for the First Human Cardiac Xenotransplantation: Combatting Rejection, Coagulopathy, Inflammation, and Excessive Growth-Reference-Cited by-同舟云学术

Genetic Engineering of Donor Pig for the First Human Cardiac Xenotransplantation: Combatting Rejection, Coagulopathy, Inflammation, and Excessive Growth

Published:2023-11 Issue:11 Volume:25 Page:1649-1656
ISSN:1523-3782
Container-title:Current Cardiology Reports
language:en
Short-container-title:Curr Cardiol Rep

Author:

Singireddy Shreya,Tully Andy,Galindo Javier,Ayares David,Singh Avneesh K.,Mohiuddin Muhammad M.^ORCID

Publisher

Springer Science and Business Media LLC

Subject

Cardiology and Cardiovascular Medicine

Link

https://link.springer.com/content/pdf/10.1007/s11886-023-01978-4.pdf

Reference54 articles.

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2. Kilic A, Mathier MA, Hickey GW, Sultan I, Morell VO, Mulukutla SR, et al. Evolving trends in adult heart transplant with the 2018 heart allocation policy change. JAMA Cardiol. 2021;6(2):159–167.

3. Griffith BP, Goerlich CE, Singh AK, Rothblatt M, Lau CL, Shah A, et al. Genetically modified porcine-to-human cardiac xenotransplantation. N Engl J Med. 2022;387(1):35–44.

4. •• Mohiuddin MM, Singh AK, Scobie L, Goerlich CE, Grazioli A, Saharia K, et al. Graft dysfunction in compassionate use of genetically engineered pig-to-human cardiac xenotransplantation: a case report. Lancet. 2023. This is the definitive postmortem analysis from the first successful pig to human solid organ xenotransplant, reviewing both the evidence for success as well as areas for further investigation.

5. Cooper DKC, Hara H, Iwase H, Yamamoto T, Li Q, Ezzelarab M, et al. Justification of specific genetic modifications in pigs for clinical organ xenotransplantation. Xenotransplantation. 2019;26(4):e12516.

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