Prognostic and therapeutic implications of myocardial viability in patients with heart failure

Author:

Soman Prem,Udelson James E.

Publisher

Springer Science and Business Media LLC

Subject

Cardiology and Cardiovascular Medicine

Reference30 articles.

1. Allman KC, Shaw LJ, Hachamovitch R, Udelson JE: Myocardial viability testing and impact of revascularization on prognosis in patients with coronary artery disease and left ventricular dysfunction: a meta-analysis. J Am Coll Cardiol 2002, 39:1151–1158. Meta-analysis of over 20 studies examining the relation of the presence or absence of viability and the influence of revascularization versus medical therapy on survival in patients with LV dysfunction. Demonstrated that patients with preserved viability are at high risk during follow-up on medical therapy, a risk that appeared to be lowered by revascularization. There appeared to be no advantage to revascularization in the absence of significant viability.

2. Gheorghiade M, Bonow RO: Chronic heart failure in the United States: a manifestation of coronary artery disease. Circulation 1998, 97:282–289.

3. Beanlands RS, Hendry PJ, Masters RG, et al.: Delay in revascularization is associated with increased mortality rate in patients with severe left ventricular dysfunction and viable myocardium on fluorine 18-fluorodeoxyglucose positron emission tomography imaging. Circulation 1998, 98:II51-II56. This important study demonstrated that patients with hibernating myocardium may benefit less from revascularization if the procedure is delayed, suggesting that hibernation is not a stable steady-state adaptation, but rather a high-risk state.

4. Luss H, Schafers M, Neumann J, et al.: Biochemical mechanisms of hibernation and stunning in the human heart. Cardiovasc Res 2002, 56:411–421.

5. Cleland JG, Pennell DJ, Ray SG, et al.: Myocardial viability as a determinant of the ejection fraction response to carvedilol in patients with heart failure (CHRISTMAS trial): randomised controlled trial. Lancet 2003, 362:14–21.

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