Should β Blockers No Longer Be Considered First-line Therapy for the Treatment of Essential Hypertension Without Comorbidities?
Author:
Publisher
Springer Science and Business Media LLC
Subject
Cardiology and Cardiovascular Medicine
Link
http://link.springer.com/content/pdf/10.1007/s11886-011-0216-z.pdf
Reference73 articles.
1. Foody JM, Farrell MH, Krumholz HM. Beta-blocker therapy in heart failure: scientific review. JAMA. 2002;287:883–9.
2. Soriano JB, Hoes AW, Meems L, Grobbee DE. Increased survival with β-blockers: importance of ancillary properties. Prog Cardiovasc Dis. 1997;39:445–56.
3. Report of the Joint National Committee on Detection, Evaluation, and Treatment of High Blood Pressure. A cooperative study. JAMA. 1977;237:255–61.
4. • Law MR, Morris JK, Wald NJ. Use of blood pressure lowering drugs in the prevention of cardiovascular disease: meta-analysis of 147 randomised trials in the context of expectations from prospective epidemiological studies. BMJ. 2009;338:b1665. The largest recent meta-analysis of cardiovascular events in trials of antihypertensive drugs, many of which include subjects without hypertension. It concludes that all antihypertensive drugs lower BP and reduce cardiovascular risk, and recommends giving the authors’ patented “polypill” (which contains low doses of 3 antihypertensive drugs) to everyone over age 50 or so years, without having to measure BP.
5. • Messerli FH, Bangalore S, Yao SS, Steinberg JS. Cardioprotection with beta-blockers: Myths, facts, and Pascal’s wager. J Intern Med. 2009;266:232–41. A nice review of the discrepancies between traditional beliefs about β blockers regarding their effectiveness in hypertension, diabetes, angina pectoris, atrial fibrillation, and the perioperative setting, and the results of recent meta-analyses about each.
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