Author:
Aalto Ulla L.,Finne-Soveri H.,Kautiainen H.,Öhman H.,Roitto H.-M.,Pitkälä K. H.
Abstract
Abstract
Objectives
Anticholinergic burden defined by the Anticholinergic Risk Scale (ARS) has been associated with cognitive and functional decline. Associations with health-related quality of life (HRQoL) have been scarcely studied. The aim of this study was to examine the association between anticholinergic burden and HRQoL among older people living in long-term care. Further, we investigated whether there is an interaction between ARS score and HRQoL in certain underlying conditions.
Design and participants
Cross-sectional study in 2017. Participants were older people residing in long-term care facilities (N=2474) in Helsinki.
Measurements
Data on anticholinergic burden was assessed by ARS score, nutritional status by Mini Nutritional Assessment, and HRQoL by the 15D instrument.
Results
Of the participants, 54% regularly used ARS-defined drugs, and 22% had ARS scores ≥2. Higher ARS scores were associated with better cognition, functioning, nutritional status and higher HRQoL. When viewing participants separately according to a diagnosis of dementia, nutritional status or level of dependency, HRQoL was lower among those having dementia, worse nutritional status, or being dependent on another person’s help (adjusted for age, sex, comorbidities). Significant differences within the groups according to ARS score were no longer observed. However, interactions between ARS score and dementia and dependency emerged.
Conclusion
In primary analysis there was an association between ARS score and HRQoL. However, this relationship disappeared after stratification by dementia, nutritional status and dependency. The reasons behind the interaction concerning dementia or dependency remain unclear and warrant further studies.
Publisher
Springer Science and Business Media LLC
Subject
Geriatrics and Gerontology,Nutrition and Dietetics,Medicine (miscellaneous)
Cited by
5 articles.
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