Modulation of FadR Binding Capacity for Acyl-CoA Fatty Acids Through Structure-Guided Mutagenesis-Reference-Cited by-同舟云学术

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Modulation of FadR Binding Capacity for Acyl-CoA Fatty Acids Through Structure-Guided Mutagenesis

Published:2015-09-18 Issue:5 Volume:34 Page:359-366
ISSN:1572-3887
Container-title:The Protein Journal
language:en
Short-container-title:Protein J

Author:

Bacik John-Paul,Yeager Chris M.,Twary Scott N.,Martí-Arbona Ricardo

Funder

Laboratory Directed Research and Development (US)

Biological and Environmental Research (US)

Publisher

Springer Science and Business Media LLC

Subject

Organic Chemistry,Biochemistry,Bioengineering,Analytical Chemistry

Link

http://link.springer.com/content/pdf/10.1007/s10930-015-9630-1.pdf

Reference28 articles.

1. van Aalten DM, DiRusso CC, Knudsen J, Wierenga RK (2000) Crystal structure of FadR, a fatty acid-responsive transcription factor with a novel acyl coenzyme A-binding fold. EMBO J 19(19):5167–5177. doi: 10.1093/emboj/19.19.5167

2. Raman N, Black PN, DiRusso CC (1997) Characterization of the fatty acid-responsive transcription factor FadR. Biochemical and genetic analyses of the native conformation and functional domains. J Biol Chem 272(49):30645–30650

3. Subrahmanyam S, Cronan JE Jr (1998) Overproduction of a functional fatty acid biosynthetic enzyme blocks fatty acid synthesis in Escherichia coli. J Bacteriol 180(17):4596–4602

4. DiRusso CC, Tsvetnitsky V, Hojrup P, Knudsen J (1998) Fatty acyl-CoA binding domain of the transcription factor FadR. Characterization by deletion, affinity labeling, and isothermal titration calorimetry. J Biol Chem 273(50):33652–33659

5. Cortay JC, Negre D, Galinier A, Duclos B, Perriere G, Cozzone AJ (1991) Regulation of the acetate operon in Escherichia coli: purification and functional characterization of the IclR repressor. EMBO J 10(3):675–679

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