Antihypertensive activity of the non-peptide angiotensin II receptor antagonist, SK&F 108566, in rats and dogs

Author:

Brooks David P.,Fredrickson Todd A.,Weinstock Joseph,Ruffolo Robert R.,Edwards Richard M.,Gellai Miklos

Publisher

Springer Science and Business Media LLC

Subject

Pharmacology,General Medicine

Reference16 articles.

1. Allen DE, Gellai M (1987) Cardioinhibitory effect of atrial peptide in conscious rats. Am J Physiol 252:R610-R616

2. Ben LK, Maselli J, Keil LC, Reid IA (1984) Role of the reninangiotensin system in the control of vasopressin and ACTH secretion during the development of renal hypertension in dogs. Hypertension 6:35–41

3. Brooks DP, Fredrickson TA (1992) Use of ameroid constrictors for the development of renin-dependent hypertension in dogs. Lab Animal Sci (in press)

4. Cangiano JL, Rodriquez-Sargent C, Martinez-Maldonado M (1979) Effects of antihypertensive treatment on systolic blood pressure and renin in experimental hypertension in rats. J Pharmacol Exp Ther 208:310–313

5. Duncia JV, Chin AT, Carini DJ, Gregory GB, Johnson AL, Price WA, Wells GJ, Wong PC, Calabrese JC, Timmermans PBMWM (1990) The discovery of potent nonpeptide angiotensin II receptor antagonists: a new class of potent antihypertensives. J Med Chem 33:1312–1329

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