Bacterial hemolysins and leukotoxins affect target cells by forming large exogenous pores into their plasma membrane. Escherichia coli hemolysin a as a case example-Reference-Cited by-同舟云学术

Bacterial hemolysins and leukotoxins affect target cells by forming large exogenous pores into their plasma membrane. Escherichia coli hemolysin a as a case example

Published:1995-12-01 Issue:6 Volume:15 Page:543-551
ISSN:0144-8463
Container-title:Bioscience Reports
language:en
Short-container-title:

Author:

Menestrina Gianfranco¹,Dalla Serra Mauro¹,Pederzolli Cecilia¹,Bregante Monica²,Gambale Franco²

Affiliation:

1. Centro CNR-ITC Fisica Stati Aggregati, Via Sommarive 14, I-38050, Povo (Trento) Italy.

2. Istituto di Cibernetica e Biofisica CNR, Via De Marini 6, I-16149 Genova, Italy.

Abstract

Many bacteria include among their virulence factors exoproteins which exert leukocidal and cytolytic functions and have the ability to form pores in model membranes. We show that, at least in the case of the RTX hemolysin produced by Escherichia coli (HlyA), formation of pores in planar lipid membranes is parallelled by opening of strikingly similar channels in the plasma membrane of exposed macrophages. Formation of such lesions in leukocytes can give rise to a variety of effects leading altogether to a diminished immune response towards the invasive bacteria.

Publisher

Portland Press Ltd.

Subject

Cell Biology,Molecular Biology,Biochemistry,Biophysics

Link

https://portlandpress.com/bioscirep/article-pdf/15/6/543/469519/bsr0150543.pdf

Reference33 articles.

1. Baumann, U., Wu, S., Flaherty, K. M. and McKay, D. B. (1993) Three-dimensional structure of the alkaline protease ofPseudomonas aeruginosa: a two-domain protein with a calcium binding beta roll motif.EMBO J. 12:3357?3364.

2. Benz, R., Schmid, A., Wagner, W. and Goebel, W. (1989) Pore formation by theEscherichia coli haemolysin: evidence for an association-dissociation equilibrium of the pore-forming aggregates.Infect. Immun. 57:887?895.

3. Benz, R., Döbereiner, A., Ludwig, A. and Goebel, W. (1992) Haemolysin ofEscherichia coli: comparison of pore-forming properties between chromosome and plasmid-encoded haemolysins.FEMS Micorbiol. Immunol. 105:55?62.

4. Benz, R., Hardie, K. R. and Hughes, C. (1994a) Pore formation in artificial membranes by the secreted hemolysins ofProteus vulgaris andMorganella morganii.Eur. J. Biochem. 220:339?347.

5. Benz, R., Maier, E., Ladant, D., Ullmann, A., Sebo, P. (1994b) Adenylate cyclase toxin (CyaA) ofBordetella pertussis. Evidence for the formation of small ion-permeable channels and comparison with HlyA ofEscherichia coli.J. Biol. Chem. 269:27231?27239.

Cited by 15 articles. 订阅此论文施引文献订阅此论文施引文献，注册后可以免费订阅5篇论文的施引文献，订阅后可以查看论文全部施引文献

1. Kingella kingae RtxA Cytotoxin in the Context of Other RTX Toxins;Microorganisms;2022-02-27

2. Understanding the pathogenesis of Flavobacterium psychrophilum using the rainbow trout monocyte/macrophage-like cell line, RTS11, as an infection model;Microbial Pathogenesis;2020-02

3. Membrane Permeabilization by Pore-Forming RTX Toxins: What Kind of Lesions Do These Toxins Form?;Toxins;2019-06-18

4. The Role of Lipid Interactions in Simulations of the α-Hemolysin Ion-Channel-Forming Toxin;Biophysical Journal;2018-11

5. Efflux Pumps Represent Possible Evolutionary Convergence onto the β-Barrel Fold;Structure;2018-09