Wnt Signaling Pathways: A Role in Pain Processing-Reference-Cited by-同舟云学术

Wnt Signaling Pathways: A Role in Pain Processing

Published:2022-01-24 Issue:3 Volume:24 Page:233-249
ISSN:1535-1084
Container-title:NeuroMolecular Medicine
language:en
Short-container-title:Neuromol Med

Author:

Tang Yiting,Chen Yupeng,Liu Rui,Li Weidong,Hua Baojin,Bao Yanju^ORCID

Abstract

AbstractThe wingless-related integration site (Wnt) signaling pathway plays an essential role in embryonic development and nervous system regulation. It is critically involved in multiple types of neuropathic pain (NP), such as HIV-related NP, cancer pain, diabetic neuralgia, multiple sclerosis-related NP, endometriosis pain, and other painful diseases. Wnt signaling is also implicated in the pain induced by sciatic nerve compression injury and selective spinal nerve ligation. Thus, the Wnt signaling pathway may be a potential therapeutic target for NP.

Funder

National Natural Science Foundation of China

Publisher

Springer Science and Business Media LLC

Subject

Cellular and Molecular Neuroscience,Neurology,Molecular Medicine

Link

https://link.springer.com/content/pdf/10.1007/s12017-021-08700-z.pdf

Reference128 articles.

1. Adler, P. N., & Lee, H. (2001). Frizzled signaling and cell–cell interactions in planar polarity. Current Opinion in Cell Biology, 13(5), 635–640.

2. Aouizerat, B. E., et al. (2010). Risk factors and symptoms associated with pain in HIV-infected adults. Journal of the Association of Nurses in Aids Care, 21(2), 125–133.

3. Ault, K. T., et al. (1996). Modulation of Xenopus embryo mesoderm-specific gene expression and dorsoanterior patterning by receptors that activate the phosphatidylinositol cycle signal transduction pathway. Development, 122(7), 2033.