Destruction of WiDr multicellular tumor spheroids with the novel thymidylate synthase inhibitor 1843U89 at physiological thymidine concentrations

Author:

Banks Sheila D.,Waters Kathleen A.,Barrett Linda L.,Dickerson Scott,Pendergast William,Smith Gary K.

Publisher

Springer Science and Business Media LLC

Subject

Pharmacology (medical),Cancer Research,Pharmacology,Toxicology,Oncology

Reference16 articles.

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2. Petrelli N, Herrera L, Rustum Y, Burke P, Creaven P, Stulc J, Emrich LJ, Mittelman A (1987) A prospective randomized trial of 5-fluorouracil versus 5-fluorouracil and high-dose leucovorin versus 5-fluorouracil and methotrexate in previously untreated patients with advanced colorectal carcinoma. J Clin Oncol 5: 1559?1565

3. Newell DR, Alison DL, Calvert AH, Harrap KR, Jarman M, Jones TR, Manteuffel-Cymborowska M, O'Connor P (1986) Pharmacokinetics of the thymidylate synthase inhibitorN 10-propargyl-5,8-dideazafolic acid (CB3717) in the mouse. Cancer Treat Rep 70: 971?979

4. Alison DL, Newell DR, Sessa C, Harland SJ, Hart LI, Harrap KR, Calvert AH (1985) The clinical pharmacokinetics of the novel antifolateN 10-propargyl-5,8-dideazafolic acid (CB3717). Cancer Chemother Pharmacol 14: 265?271

5. Judson I, Clarke S, Ward J, Sutcliffe F, Planting A, Spiers J, Smith R, Verweij J (1992) Pharmacokinetics of ICI D1694 following a 15-min infusion in patients with advanced cancer. Proc 28th Annu Meet Am Soc Clin Oncol 11: 117

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