A comparison of the inhibition of deacetylase in primary cultures of rat and human hepatocytes effecting metabolism and DNA-binding of 2-acetylaminofluorene

Author:

Monteith David K.,Strom Stephen C.

Publisher

Springer Science and Business Media LLC

Subject

Health, Toxicology and Mutagenesis,Cell Biology,Toxicology

Reference36 articles.

1. AUNE, T., VANDERSLICE, R.R., CROFT, J.E., DYBING, E., BEND, J.R. and PHILPOT, R.M. (1985). Deacetylation to 2-aminofluorene as a major initial reaction in the microsomal metabolism of 2-acetylaminofluorene to mutagenic products in preparations from rabbit lung and liver. Cancer Res.45:5859–5866.

2. BELAND, F.A., ALLABEN, W.T. and EVANS, F.E. (1980). Aceyltransferase-mediated binding of N-Hydroxyarylamides to nucleic acids. Cancer Res.40:834–840.

3. BERANEK, D.T., WHITE, G.L., HEFLICH, R.H. and BELAND, F.A. (1982). Aminofluorence-DNA adduct formation inSalmonella typhimurium exposed to the carcinogen N-hydroxy-2-acetylaminofluorene. Proc. Natl. Acad. Sci.70:5175–5178.

4. BLAABOER, B.J., VAN HOLSTEIJN, I., VAN GRAFT, M. and PAINE, A.J. (1985). The concentration of cytochrome P-450 in human hepatocyte culture. Biochem. Pharmacol.34:2405–2408.

5. DEBAUN, J.R., MILLER, E.C. and MILLER, J.A. (1970). N-Hydroxy-2-acetylaminofluorene sulfotransferase: Its probable role in carcinogenesis and in protein-(methion-S-yl) binding in rat liver. Cancer Res.30:577–595.

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