Expression of cefD2 and the conversion of isopenicillin N into penicillin N by the two-component epimerase system are rate-limiting steps in cephalosporin biosynthesis-Reference-Cited by-同舟云学术

Expression of cefD2 and the conversion of isopenicillin N into penicillin N by the two-component epimerase system are rate-limiting steps in cephalosporin biosynthesis

Published:2004-11-18 Issue:5 Volume:272 Page:562-570
ISSN:1617-4615
Container-title:Molecular Genetics and Genomics
language:en
Short-container-title:Mol Genet Genomics

Author:

Ullán R. V.,Casqueiro J.,Naranjo L.,Vaca I.,Martín J. F.

Publisher

Springer Science and Business Media LLC

Subject

Genetics,Molecular Biology,General Medicine

Link

http://link.springer.com/content/pdf/10.1007/s00438-004-1087-4.pdf

Reference33 articles.

1. Aharonowitz Y, Cohen G, Martín JF (1992) Penicillin and cephalosporin biosynthetic genes: structure, organization, regulation and evolution. Annu Rev Microbiol 46:461–495

2. Barredo JL, Díez E, Álvarez E, Martín JF (1989) Large amplification of a 35-kb DNA fragment carrying two penicillin biosynthetic genes in high penicillin producing strains of Penicillium chrysogenum. Curr Genet 16:453–459

3. Bradford MM (1976) A rapid and sensitive method for the quantitation of microgram quantities of protein utilizing the principle of protein-dye binding. Anal Biochem 72:248–254

4. Díez B, Barredo JL, Álvarez E, Cantoral JM, van Solingen P, Groenen MA, Veenstra AE, Martín JF (1989) Two genes involved in penicillin biosynthesis are linked in a 5.1-kb Sal I fragment in the genome of Penicillium chrysogenum. Mol Gen Genet 218:572–576

5. Elander RP (2003) Industrial production of β-lactam antibiotics. Appl Microbiol Biotechnol 61:385–392

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