Population Pharmacokinetic Modeling of JNJ-53718678, a Novel Fusion Inhibitor for the Treatment of Respiratory Syncytial Virus: Results from a Phase I, Double-Blind, Randomized, Placebo-Controlled First-in-Human Study in Healthy Adult Subjects

Author:

Huntjens Dymphy R. H.,Ouwerkerk-Mahadevan Sivi,Brochot Anne,Rusch Sarah,Stevens Marita,Verloes Rene

Funder

Janssen Pharmaceutica NV, Belgium.

Publisher

Springer Science and Business Media LLC

Subject

Pharmacology (medical),Pharmacology

Reference15 articles.

1. Enders G. Chapter 59. Paramyxoviruses. In: Baron S, editor. Medical microbiology. 4th ed. Galveston, Tex: University of Texas Medical Branch at Galveston; 1996.

2. Mazur NI, Martinón-Torres F, Baraldi E, in collaboration with Respiratory Syncytial Virus Network (ReSViNET), et al. Lower respiratory tract infection caused by respiratory syncytial virus: current management and new therapeutics. Lancet. Respir Med. 2015;3:888–900.

3. Nair H, Nokes JD, Gessner BD, et al. Global burden of acute lower respiratory infections due to respiratory syncytial virus in young children: a systematic review and meta-analysis. Lancet. 2010;375:1545–55.

4. National Center for Immunization and Respiratory Diseases (NCIRD), Division of Viral Diseases. 2014. Available from: http://www.cdc.gov/rsv/about/index.html . Accessed 15 Mar 2016.

5. Paes BA, Mitchell I, Banerji A, et al. A decade of respiratory syncytial virus epidemiology and prophylaxis: translating evidence into everyday clinical practice. Can Respir J. 2011;18:e10–9.

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