Evaluation of the Influence of Sildenafil on the Safety, Tolerability, Pharmacokinetics, and Pharmacodynamics of Vericiguat in Healthy Adults

Author:

Boettcher MichaelORCID,Nowotny BettinaORCID,Krausche Robert,Becker CorinaORCID

Funder

This study was funded by Bayer AG and Merck Sharp & Dohme LLC, a subsidiary of Merck & Co., Inc., Rahway, NJ, USA

Publisher

Springer Science and Business Media LLC

Subject

Pharmacology (medical),Pharmacology

Reference15 articles.

1. US Food and Drug Administration. Verquvo™ (vericiguat) tablets: highlights of prescribing information. 2021. https://www.accessdata.fda.gov/drugsatfda_docs/label/2021/214377s000lbl.pdf. Accessed 11 May 2022.

2. European Medicines Agency. Verquvo. 2021. https://www.ema.europa.eu/en/medicines/human/EPAR/verquvo. Accessed 16 January 2023.

3. McDonagh TA, Metra M, Adamo M, Gardner RS, Baumbach A, Böhm M, et al. 2021 ESC guidelines for the diagnosis and treatment of acute and chronic heart failure: developed by the Task Force for the Diagnosis and Treatment of Aacute and Chronic Heart Failure of the European Society of Cardiology (ESC) with the special contribution of the Heart Failure Association (HFA) of the ESC. Eur Heart J. 2021;42(36):3599–726.

4. Armstrong PW, Pieske B, Anstrom KJ, Ezekowitz J, Hernandez AF, Butler J, et al. Vericiguat in patients with heart failure and reduced ejection fraction. N Engl J Med. 2020;382(20):1883–93.

5. US Food and Drug Administration. Viagra® (sildenafil citrate) tablets: highlights of prescribing information. 2014. https://www.accessdata.fda.gov/drugsatfda_docs/label/2014/20895s039s042lbl.pdf. Accessed 7 Sept 2021.

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