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Avelumab Dose Selection for Clinical Studies in Pediatric Patients with Solid Tumors

  • Published:2022-04-29 Issue:7 Volume:61 Page:985-995
  • ISSN:0312-5963
  • Container-title:Clinical Pharmacokinetics
  • language:en
  • Short-container-title:Clin Pharmacokinet

Author:

Vugmeyster Yulia,Grisic Ana-Marija,Brockhaus Brigitte,Rueckert Peter,Ruisi Mary,Dai Haiqing,Khandelwal Akash

Funder

Merck KGaA

Pfizer

Publisher

Springer Science and Business Media LLC

Subject

Pharmacology (medical),Pharmacology

Reference21 articles.

1. Geoerger B, Kang HJ, Yalon-Oren M, Marshall LV, Vezina C, Pappo A, et al. Pembrolizumab in paediatric patients with advanced melanoma or a PD-L1-positive, advanced, relapsed, or refractory solid tumour or lymphoma (KEYNOTE-051): interim analysis of an open-label, single-arm, phase 1–2 trial. Lancet Oncol. 2020;21(1):121–33. https://doi.org/10.1016/S1470-2045(19)30671-0.

2. Geoerger B, Zwaan CM, Marshall LV, Michon J, Bourdeaut F, Casanova M, et al. Atezolizumab for children and young adults with previously treated solid tumours, non-Hodgkin lymphoma, and Hodgkin lymphoma (iMATRIX): a multicentre phase 1–2 study. Lancet Oncol. 2020;21(1):134–44. https://doi.org/10.1016/S1470-2045(19)30693-X.

3. Davis KL, Fox E, Merchant MS, Reid JM, Kudgus RA, Liu X, et al. Nivolumab in children and young adults with relapsed or refractory solid tumours or lymphoma (ADVL1412): a multicentre, open-label, single-arm, phase 1–2 trial. Lancet Oncol. 2020;21(4):541–50. https://doi.org/10.1016/S1470-2045(20)30023-1.

4. Shemesh CS, Chanu P, Jamsen K, Wada R, Rossato G, Donaldson F, et al. Population pharmacokinetics, exposure-safety, and immunogenicity of atezolizumab in pediatric and young adult patients with cancer. J Immunother Cancer. 2019;7(1):314. https://doi.org/10.1186/s40425-019-0791-x.

5. Novakovic AM, Wilkins JJ, Dai H, Wade JR, Neuteboom B, Brar S, et al. Changing body weight-based dosing to a flat dose for avelumab in metastatic Merkel cell and advanced urothelial carcinoma. Clin Pharmacol Ther. 2020;107(3):588–96. https://doi.org/10.1002/cpt.1645.

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