Quantification of the Time Course of CYP3A Inhibition, Activation, and Induction Using a Population Pharmacokinetic Model of Microdosed Midazolam Continuous Infusion-Reference-Cited by-同舟云学术

Quantification of the Time Course of CYP3A Inhibition, Activation, and Induction Using a Population Pharmacokinetic Model of Microdosed Midazolam Continuous Infusion

Published:2022-10-04 Issue:11 Volume:61 Page:1595-1607
ISSN:0312-5963
Container-title:Clinical Pharmacokinetics
language:en
Short-container-title:Clin Pharmacokinet

Author:

Nassar Yomna M.^ORCID,Hohmann Nicolas,Michelet Robin^ORCID,Gottwalt Katharina,Meid Andreas D.,Burhenne Jürgen,Huisinga Wilhelm^ORCID,Haefeli Walter E.^ORCID,Mikus Gerd^ORCID,Kloft Charlotte

Funder

Department of Clinical Pharmacology and Pharmacoepidemiology at Heidelberg University Hospital and the Department of Clinical Pharmacy and Biochemistry at the Freie Universitaet Berlin

Freie Universität Berlin

Publisher

Springer Science and Business Media LLC

Subject

Pharmacology (medical),Pharmacology

Link

https://link.springer.com/content/pdf/10.1007/s40262-022-01175-6.pdf

Reference37 articles.

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2. Paine MF, Shen DD, Kunze KL, Perkins JD, Marsh CL, McVicar JP, et al. First-pass metabolism of midazolam by the human intestine. Clin Pharmacol Ther. 1996;60:14–24. https://doi.org/10.1016/S0009-9236(96)90162-9.

3. Thummel KE, Wilkinson GR. In vitro and in vivo drug interactions involving human CYP3A. Annu Rev Pharmacol Toxicol. 1998;38:389–430. https://doi.org/10.1146/annurev.pharmtox.38.1.389.

4. Nagar S, Argikar UA, Tweedie DJ. Reversible mechanisms of enzyme inhibition and resulting clinical significance. In: Enzyme kinetics in drug metabolism: fundamentals and applications, Vol. 1113. Totowa: Humana Press; 2014; pp 37–56. doi: https://doi.org/10.1007/978-1-62703-758-7_1.