Evidence-Based Design of Fixed-Dose Combinations: Principles and Application to Pediatric Anti-Tuberculosis Therapy

Author:

Svensson Elin M.ORCID,Yngman Gunnar,Denti Paolo,McIlleron Helen,Kjellsson Maria C.,Karlsson Mats O.

Funder

Vetenskapsrådet

Swedish Foundation for International Cooperation in Research and Higher Education

Innovative Medicines Initiative Joint Undertaking for the PreDiCT-TB consortium

South African National Research Council

Eunice Kennedy Shriver National Institute of Child Health and Human Development

Publisher

Springer Science and Business Media LLC

Subject

Pharmacology (medical),Pharmacology

Reference54 articles.

1. Bangalore S, Kamalakkannan G, Parkar S, Messerli FH. Fixed-dose combinations improve medication compliance: a meta-analysis. Am J Med. 2007;120:713–9.

2. Connor J, Rafter N, Rodgers A. Do fixed-dose combination pills or unit-of-use packaging improve adherence? A systematic review. Bull World Health Organ. 2004;82:935–9.

3. Blomberg B, Spinaci S, Fourie B, Laing R. The rationale for recommending fixed-dose combination tablets for treatment of tuberculosis. Bull World Health Organ. 2001;79:61–8.

4. Blanco JL, Montaner JSG, Marconi VC, Santoro MM, Campos-Loza AE, Shafer RW, et al. Lower prevalence of drug resistance mutations at first-line virological failure to first-line therapy with atripla vs. tenofovir  +  emtricitabine/lamivudine  +  efavirenz administered on a multiple tablet therapy. AIDS. 2014;28:2531–9.

5. Moulding TS, Le HQ, Rikleen D, Davidson P. Preventing drug-resistant tuberculosis with a fixed dose combination of isoniazid and rifampin. Int J Tuberc Lung Dis. 2004;8:743–8.

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