Cholesterol as a target for toxins-Reference-Cited by-同舟云学术

Cholesterol as a target for toxins

Published:1990-04-01 Issue:2 Volume:10 Page:127-130
ISSN:0144-8463
Container-title:Bioscience Reports
language:en
Short-container-title:

Author:

de Kruijff B.¹

Affiliation:

1. Centre for Biomembranes and Lipid Enzymology and Institute of Molecular Biology and Medical Biotechnology, University of Utrecht, Padualaan 8, 3584 CH, Utrecht, NL

Abstract

A mechanism is proposed for the way in which cholesterol facilitates channel formation by polyene antibiotics and bacterial protein toxins. Central elements of the model are: (i) interactions between the ring system of the sterol and rigid elements of the polyene or toxin molecule, and (ii) the specific orientation of cholesterol within the membrane.

Publisher

Portland Press Ltd.

Subject

Cell Biology,Molecular Biology,Biochemistry,Biophysics

Link

https://portlandpress.com/bioscirep/article-pdf/10/2/127/468091/bsr0100127.pdf

Reference12 articles.

1. Bolard, J. (1986)Biochim. Biophys. Acta 864:257?304.

2. Finkelstein, A. and Holz, R. (1973) In:Membranes, Lipid Bilayers and Antibiotics (G. Eisenman, ed.), Vol. 2, Marcel Dekker, New York, pp. 378?403.

3. Andreoli, T. E. (1974)Ann. N.Y. Acad. Sci. 235:448?468.

4. De Kruijff, B. and Demel, R. A. (1974)Biochim. Biophys. Acta 339:57?70.

5. Dufourc, E. J., Parrish, E. J., Chitrakorn, S. and Smith, I. C. P. (1984)Biochemistry 23:6062?6071.

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