Formation and degradation of deoxyadenosine nucleotides in inherited adenosine deaminase deficiency
Author:
Affiliation:
1. Purine Laboratory, Guy's Hospital, London, SE1 9RT, U.K.
2. Medical Unit, St. Bartholomew's Hospital, London, EC1A 7BE, U.K.
3. Department of Immunology, Institute of Child Health, London, WC1N 1EH, U.K.
Publisher
Portland Press Ltd.
Subject
Cell Biology,Molecular Biology,Biochemistry,Biophysics
Link
https://portlandpress.com/bioscirep/article-pdf/2/5/303/469948/bsr0020303.pdf
Reference20 articles.
1. Carson DA, Kaye J, Matsumoto S, Seegmiller JE & Thompson L (1979) Biochemical basis for the enhanced toxicity of deoxyribonucleosides toward malignant human T-cell lines. Proc. Natl. Acad. Sci. U.S.A.76, 2430?2433.
2. Hershfield MS & Kredich NM (1980) Resistance of an adenosine kinase-deficient human lymphoblast cell line to effects of deoxyadenosine on growth, S-adenosyl homocysteine hydrolase inactivation and dATP accumulation. Proc. Natl. Acad. Sci. U.S.A.77, 4292?4296.
3. Ballet J-J, Insel R, Merler E & Rosen FS (1976) Inhibition of maturation of human precursor lymphocytes by coformycin, an inhibitor of the enzyme adenosine deaminase. J. Exper. Med.143, 1271?1276.
4. Simmonds HA, Sahota A, Potter CF, Perrett D, Hugh-Jones K & Watson JG (1979) Purine metabolism in adenosine deaminase deficiency. InEnzyme Defects and Immune Dysfunction, Ciba Symposium 68 (new series). Excerpta Medica, 255?262.
5. Cohen A, Hirshorn R, Horowitz SD, Rubenstein A, Polmar SH, Hong R & Martin DW (1978) Deoxyadenosine triphosphate as a potentially toxic metabolite in adenosine deaminase deficiency. Proc. Natl. Acad. Sci. U.S.A.75, 472?476.
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