Author:
Zöller N.,Kippenberger S.
Abstract
AbstractImpaired wound healing, imbalanced fibroblast proliferation, and extracellular matrix synthesis are associated with aberrant scarring. The impact of impaired wound healing can be tremendous due to physical restrictions, high recurrence rates, stigmatization, and secondary infections in chronic wounds. It is therefore essential to develop alternative treatment regimens to those that are currently used. The highly diverse influence of water-filtered infrared-A (wIRA) on cell metabolism, bacterial colonisation, wound healing, and its high tissue penetration – reaching the subcutis without inducing harmful increases in skin surface temperature or pain – led to the investigation of the influence of the spectral and thermal component of wIRA on normal and keloid fibroblasts in vitro. Data show the potential value of the spectral and the thermal component of wIRA as an adjuvant therapy for aberrant scarring due to its differential influence on the proliferation, migration, and collagen type I synthesis of normal and keloid fibroblasts. The observed aspects in the context of hypertrophic scar treatment need to be evaluated in further basic research and clinical studies.
Publisher
Springer International Publishing