Mechanisms of PARP Inhibitor Resistance

Author:

O’Connor Mark J.,Forment Josep V.

Publisher

Springer International Publishing

Reference86 articles.

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2. Bryant HE, Schultz N, Thomas HD, Parker KM, Flower D, Lopez E et al (2005) Specific killing of BRCA2-deficient tumours with inhibitors of poly(ADP-ribose) polymerase. Nature 434:913. https://doi.org/10.1038/nature03443 https://www.nature.com/articles/nature03443#supplementary-information

3. McCabe N, Turner NC, Lord CJ, Kluzek K, Białkowska A, Swift S et al (2006) Deficiency in the repair of DNA damage by homologous recombination and sensitivity to poly(ADP-Ribose) polymerase inhibition. Can Res 66(16):8109–8115. https://doi.org/10.1158/0008-5472.Can-06-0140

4. Pellegrino B, Herencia-Ropero A, Llop-Guevara A, Pedretti F, Moles-Fernández A, Viaplana C et al (2022) Preclinical in vivo validation of the RAD51 test for identification of homologous recombination-deficient tumors and patient stratification. Can Res 82(8):1646–1657. https://doi.org/10.1158/0008-5472.CAN-21-2409

5. Pujade-Lauraine E, Ledermann JA, Selle F, Gebski V, Penson RT, Oza AM et al (2017) Olaparib tablets as maintenance therapy in patients with platinum-sensitive, relapsed ovarian cancer and a BRCA1/2 mutation (SOLO2/ENGOT-Ov21): a double-blind, randomised, placebo-controlled, phase 3 trial. Lancet Oncol 18(9):1274–1284. https://doi.org/10.1016/S1470-2045(17)30469-2

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