Metabolites of Tamoxifen as the Basis of Drug Development

Author:

Maximov Philipp Y.,McDaniel Russell E.,Jordan V. Craig

Publisher

Springer Basel

Reference138 articles.

1. Jordan VC, Collins MM, Rowsby L, Prestwich G (1977) A monohydroxylated metabolite of tamoxifen with potent antioestrogenic activity. J Endocrinol 75:305–316

2. Allen KE, Clark ER, Jordan VC (1980) Evidence for the metabolic activation of non-steroidal antioestrogens: a study of structure-activity relationships. Br J Pharmacol 71:83–91

3. Borgna JL, Rochefort H (1981) Hydroxylated metabolites of tamoxifen are formed in vivo and bound to estrogen receptor in target tissues. J Biol Chem 256:859–868

4. Jordan VC, Dix CJ, Naylor KE et al (1978) Nonsteroidal antiestrogens: their biological effects and potential mechanisms of action. J Toxicol Environ Health 4:363–390

5. Lien EA, Solheim E, Kvinnsland S, Ueland PM (1988) Identification of 4-hydroxy-N-desmethyltamoxifen as a metabolite of tamoxifen in human bile. Cancer Res 48:2304–2308

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