Author:
Montesinos López Osval Antonio,Montesinos López Abelardo,Crossa Jose
Abstract
AbstractThe fundamentals for Reproducing Kernel Hilbert Spaces (RKHS) regression methods are described in this chapter. We first point out the virtues of RKHS regression methods and why these methods are gaining a lot of acceptance in statistical machine learning. Key elements for the construction of RKHS regression methods are provided, the kernel trick is explained in some detail, and the main kernel functions for building kernels are provided. This chapter explains some loss functions under a fixed model framework with examples of Gaussian, binary, and categorical response variables. We illustrate the use of mixed models with kernels by providing examples for continuous response variables. Practical issues for tuning the kernels are illustrated. We expand the RKHS regression methods under a Bayesian framework with practical examples applied to continuous and categorical response variables and by including in the predictor the main effects of environments, genotypes, and the genotype ×environment interaction. We show examples of multi-trait RKHS regression methods for continuous response variables. Finally, some practical issues of kernel compression methods are provided which are important for reducing the computation cost of implementing conventional RKHS methods.
Funder
Bill and Melinda Gates Foundation
Publisher
Springer International Publishing
Reference42 articles.
1. Akhiezer NI, Glazman IM (1963) Theory of linear operators in Hilbert Space (Teoriia lineikykh operatorov v Gil’bertovom prostranstve), vol 1. M. Nestell, trans. from Russian. Frederick Ungar, New York
2. Buil A, Brown AA, Lappalainen T, Viñuela A, Davies MN, Zheng HF, Richards JB, Glass D, Small KS, Durbin R et al (2015) Gene-gene and gene-environment interactions detected by transcriptome sequence analysis in twins. Nat Genet 47:88–91
3. Cho Y, Saul LK (2009) Kernel methods for deep learning. In: NIPS’09 proceedings of the 22nd international conference on neural information processing systems, pp 342–350
4. Cordell HJ (2002) Epistasis: what it means, what it doesn’t mean, and statistical methods to detect it in humans. Hum Mol Genet 11:2463–2468
5. Cordell HJ (2009) Detecting gene-gene interactions that underlie human diseases. Nat Rev Genet 10:392–404
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