A Deep Learning-Based Method for Uncovering GPCR Ligand-Induced Conformational States Using Interpretability Techniques
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Publisher
Springer International Publishing
Link
https://link.springer.com/content/pdf/10.1007/978-3-031-07802-6_23
Reference40 articles.
1. Amitai, G., et al.: Network analysis of protein structures identifies functional residues. J. Mol. Biol. 344(4), 1135–1146 (2004)
2. Bach, S., Binder, A., Montavon, G., Klauschen, F., Müller, K.R., Samek, W.: On pixel-wise explanations for non-linear classifier decisions by layer-wise relevance propagation. PLoS ONE 10(7), e0130140 (2015)
3. Bajorath, J., et al.: Artificial intelligence in drug discovery: Into the great wide open. J. Med. Chem. 63(16), 8651–8652 (2020)
4. Bera, I., Payghan, P.V.: Use of molecular dynamics simulations in structure-based drug discovery. Curr. Pharm. Des. 25(31), 3339–3349 (2019)
5. Brinda, K., Vishveshwara, S.: A network representation of protein structures: implications for protein stability. Biophys. J . 89(6), 4159–4170 (2005)
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