Methods and Materials for Drug Eluting Urinary Stents Design and Fabrication

Abstract

AbstractAfter urinary stenting, patients often suffer from mid- and long-term complications, such as infections, bacterial colonization, encrustations, or stent obstruction which are related to the design, materials and surface properties of the stent. Drug eluting stents (DES) is an advance technology that can reduce the morbidity associated with stenting, by locally releasing loaded drugs in a time-controlled manner. In this chapter is firstly reported an overview of the materials and manufacturing methods for conventional urinary stents, then are discussed the engineered strategies for the design and fabrication of drug eluting stents. Drug eluting ureteral stents, and in general urinary stents, were introduced to performed a drug delivery aiming to obtain a local treatment as well as to overcomes the main issues related to urinary stenting implantation. Drugs and/or active agents can be directly loaded in the stent structure or can be introduced through a surface coating. Drug-eluting technologies can then be combined with biodegradable stents in order to eliminate the need for stent removal procedure. However some disadvantages remain still unsolved. In the last decades innovative manufacturing approaches and methods, such as nanotechnologies and additive manufacturing techniques, provide to scientists new tools for the design and fabrication on smart and custom-made urinary stents, able to go towards perfectly to patient needs.