The Regulatory Subunit of cAMP-Dependent Protein Kinase as a Target for Cancer Diagnosis and Therapy

Author:

Cho-Chung Y. S.,Cereseto A.,Budillon A.,Clair T.,Rohlff Ch.

Publisher

Birkhäuser Basel

Reference59 articles.

1. Ally, S., Tortora, G., Clair, T., Grieco, D., Merlo, G., Katsaros, D., Ogreid, D., Doskeland, S. O., Jahnsen, T., and Cho-Chung, Y. S. (1988) Selective modulation of protein kinase isozymes by the site-selective analog 8-chloroadenosine 3’,5’-cyclic monophosphate provides a biological means for control of human colon cancer cell growth. Proc. Natl. Acad. Sci. U.S.A. 85: 6319–6322.

2. Beebe, S. J., and Corbin, J. D. (1986) Cyclic nucleotide-dependent protein kinases. In: Boyer, P. D., and Kerbes, E. G., eds. The Enzymes: Control by Phosphorylation. Part A, Vol. 17, Academic Press, New York.

3. Beebe, S. J., Holloway, R., Rannels, S. R., and Corbin, J. D. (1984) Two classes of cAMP analogs which are selective for the two different cAMP-binding sites of type II protein kinase demonstrate synergism when added together to intact adipocytes. J. Biol. Chem. 259: 3539–3547.

4. Beebe, S. J., Oyen, O., Sandberg M., Froysa, A., Hansson, V., and Jahnsen, T. (1990) Molecular cloning of a unique tissue-specific protein kinase (C) from human testis -representing a third isoform for the catalytic subunit of the cAMP-dependent protein kinase. Mol.Endocr. 4:465–475.

5. Bradbury, A. W., Miller, W. R., Clair, T., Yokozaki, H., and Cho-Chung, Y. S. (1990) Overexpressed type I regulatory subunit (RI) of cAMP-dependent protein kinase (PKA) as tumor marker in colorectal cancer. Proc. Am. Ass. Cancer Res. 31:172.

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